The effects of a drug can be grouped into three different kinds of effects:
Upsides – the effects you’re hoping for when you use it; the good, nice effects
Downsides – the not-so-good effects that happen while you’re taking the drug, but which you hope won’t happen
Long term – the ways in which the drug affects your mind and body after you’ve been using it for a long time – months and years. Long term effects are generally downsides.